Wednesday, January 27, 2016
Monday, January 25, 2016
FULL TRANSCRIPT WITH SLIDE SCREENSHOTS
Hello. Thank you for joining us at the GMO Free News. I am joined today. I am Kathleen Hallal. My co-host is Rachel Linden. We’re joined by our producer Jack Ohlmstead and Zoey O’Toole from The Thinking Moms Revolution.
And our guest today is Lucija Tomljenovic, a scientist who has done a lot of research on vaccines and the reactions to vaccines especially focusing on the antibody reactions and what happens in the brain neurologically when the adjuvants hit the brain and the vaccines sort of do their thing.
And Dr. Tomljenovic is going to show us a PowerPoint and I thought maybe we could start off with that if that’s all right. And Lucija I’d like to welcome you to the show and thank you so much for the work you are doing. Let’s start with your PowerPoint and then we’ll ask questions afterward.
Dr. Lucija Tomljenovic:Ok Thank you Kathleen. Let me bring it up. So does everyone see the PowerPoint? Ok. So I just skipping introduction. I work at the University of British Columbia for the listeners who may not know that. And one of the central questions that we have been asking is Why would an immune challenge such as vaccination affect the brain in any way?
So basically there are many immune molecules that are actually expressed both in the developing nervous system and the adult nervous system. Things like immune cytokines, members of the complement cascade. I know these are scientific terms but these are all part of the, these are immune system mediators that are expressed in the brain at specific times of development and they actually regulate the development of the brain. I will give here, one example because we are going to touch on the issue of autism. One of the aberrations in autism that is found neuro-pathologically is abnormal brain connectivity so certain regions are over connected while some regions are under connected. And we know that early in the development what happens is there is an excessive number of synaptic connections that is formed and it's the complement part of the immune system cascade that actually targets the excessive synapses for elimination and it does that at specific times of brain development.
So again and this is another publication showing, emphasizing the same fact, touching on the issue that if you disturb the balance of immune mediators in the brain during critical periods of brain development you can obviously adversely affect neurodevelopment.
And so again what is firmly established in the literature where it's clearly seen from publications, data, even more than ten years in the past is that immune central nervous system cross-talk is the norm rather than the exception.
And the level of interaction between the two systems is actually very complex and occurs at multiple levels and it has actually been termed as the immuno neuro endocrine network because it involves the immune system, it involves the central nervous system and it involves endocrine system, so if there is interference at any one of these levels you can get major problems because this network plays major roles in not just brain function and brain development but also in maintenance of general homeostasis and also immune regulation.
And here is a selection of publications, the one at the top is from 1995, so scientists in 1995, knew that that neuro endocrine immune system had a link with autoimmune diseases and that neuro-immune disease pathways are connected to inflammatory disease so again this is nothing new so why do the vaccinologists ignore this link?
I took a list of these and wanted to see how many of these functions on the list are actually affected in autism, all of them minus the last two (food intake, thermoregulation).
So these are all the neuroendocrine defects in autism and on the right hand side you have the references and same goes for I couldn’t find any effect on food intake and thermoregulation. We know some autistic kids are underweight but that is because of various food sensitivities and the inflammation in the gut.
And then again if you look at the literature there is compelling evidence that some cytokines are increased in autistic brains, IL-6 is one of them, and if you do experimental manipulations in mice where you administer to mice IL-6 then you will reproduce some autism like behaviors in these animals.
Next one is a neuropathological study that examined the level of pro-inflammatory cytokines in the brains of autistic patients and again found a number of elevated immune mediators in the brain again there is compelling evidence that there is an increase of inflammation in brains of autistic patients. This should not be rocket science.
This is a publication that we recently published by our group which discusses the effect of aluminum adjuvants.
First thing we’ll show gene expression in brains of male mice. there are a number of genes were found up-regulated. and a number of genes found down-regulated. This was just gene expression changes.
I have one question. You had said that females have more estrogen which protects the brain so there are fewer girls found on the autism spectrum but at the bottom of this slide it says females severely affected.
It’s not black and white because in this particular test, we have seen females even on one measured parameter had showed effective at lower dose. It’s only one measured parameter but I’m not discarding it. The effects are not black and white. This is just one test and we have done a number of others.
For us the most interesting one was social interactions. Here we measured social interaction. Mice will explore object or interact with a companion mouse. We saw both in males and females significant reduction in interaction between mouse and mouse, not between mouse and an object, but yes between mouse and mouse. This was very interesting because that is one of the core deficits in autism, which is abnormal social activity.
Closely spaced immune stimulus that basically cause increased level of inflammatory cytokines in the brain, but not just that again every time you stimulate the immune system the brain will respond and if you cross a certain threshold you will impact in a negative way the regulation and the function of the immuno neuro-endocrine network. The reason why aluminum is added in vaccines, and not all vaccines, aluminum is not present in live attenuated vaccines such as MMR, or inactivated polio vaccine, or varicella vaccine, so BCG, any vaccine that contains a live agent which has been attenuated and weakened does not contain aluminum because the whole infectious agent is enough to stimulate the immune system. So if you would give kids 10 shots of MMR spaced every two months, it wouldn't grow well so again I just want to emphasize that it’s not aluminum that’s causing the problem even though the issue with aluminum is not only that it's an immune adjuvant but it's also a neurotoxin, so it causes double damage in that respect.
As I believe you are aware, there are many mice that are genetically modified so they will spontaneously develop autoimmune disease, and if you challenge them with certain immunotoxic compound you will only speed up the development of autoimmunity. But what the research from Japan has shown, that even in mice that are not prone, they are wild mice, if you stimulate them in excess, and what they’ve done in this experiment, they have administered antigen every five days eight times, and again, this was eight week old mice, not neonatal mice, five days apart, you would not translate to five days apart in humans because mice only live a couple of years.
So the key problem is not single vaccines. The key problem is the the closely spaced vaccinations. This is the U.S. schedule from 2015 birth to 6 years and basically you see multiple antigens repeatedly administered every couple of months which is simply insanity. it's asking for trouble.